Noopept powder CAS 157115-85-0

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N-Phenylacetyl-l-prolylglycine ethyl ester is promoted as a nootropic and is a prodrug of cyclic glycine-proline.Other names include the brand name Noopept (Russian: Ноопепт), developmental code GVS-111; proposed INN omberacetam.

Its synthesis was first reported in 1996.It is orally available, as of 2017 its metabolism and elimination half-life were not well understood, and cycloprolylglycine has not been measured in humans following administration.In cell culture, cycloprolylglycine increases brain derived neurotrophic factor (BDNF).

It has been evaluated for neuroprotective effects in treating brain injuries and stroke.

 

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Noopept powder CAS 157115-85-0

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Noopept powder CAS 157115-85-0 product information:

Product Name: Noopept powder
Alternate Name 1-(2-Phenylacetyl)-L-prolyl-glycine ethyl ester; or N-Phenylacetyl-L-prolylglycine ethyl ester; SGS-111; GVS 111
Appearance White powder
CAS NO 157115-85-0
Molecular Formula C₁₇H₂₂N₂O₄
Molecular Weight 318.4
Purity ≥98% by TLC
Solubility DMSO (25 mg/ml)
SMILES CCOC(=O)CNC(=O)C1CCCN1C(=O)CC2=CC=CC=C2
InChi InChI=1S/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1
InChi Key PJNSMUBMSNAEEN-AWEZNQCLSA-N
PubChem CID 180496
MDL Number MFCD00941121
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Noopept vs Piracetam: Differences & What’s Better?

Potency and Bioavailability

Based on the available research, Piracetam is most effective for those with existing cognitive problems.

Piracetam is absorbed and utilized well by the human body. This shows its good bioavailability. It has a longer half-life than other nootropics like aniracetam.

Noopept, when compared to Piracetam, does not have very good bioavailability. Thus, Noopept is best taken sublingually for its better absorption into the human body.

Others often stack it with Alpha GPC to achieve better results. Despite its low bioavailability, Noopept is more potent than Piracetam as it uses lower concentrations and its effects show up faster.

Noopept vs Piracetam: Which is Better?

Nootropics like these depend on the goals and conditions of the user. Medical advice for Piracetam and Noopept is generally scattered and still being researched to understand further how they work for the body.

Piracetam is a tried-and-tested nootropic but is not as potent as Noopept. On the other hand, Noopept is a newer nootropic but has gained popularity in the biohacking and nootropics community for its potency.

 

Noopept vs Adrafinil:What You MUST Know?

Additionally, there are many differences between the two compounds. First and for emostthey are completely different structurally, resulting in different mechanisms of action. While adrafinil is part of a class widely known as “afinils,” Noopept is considered a type of racetam.
Because of this, their nootropic effects differ slightly. Adrafinil’s main effect is to promoteenergy and alertness-after all, its intended original use was as a wakefulness agent forpeople with sleep disorders. On the other hand, Noopept seems to have a more direct effecton cognition, and may also help increase confidence and reduce anxiety. Noopept also appears to have some neuroprotective properties
Noopept is also significantly more potent on a milligram-by-milligram basis, with a typicadose of 10-30 mg, whereas the typical dose of adrafinil is about 300 mg according tonootropics researchers.
There are also some differences in their legal status around the world. ln the United StatesCanada, and the United Kingdom, adrafinil is not classified as a prescription drug-andtherefore is able to be purchased online for research purposes. However, it requires aprescription in Australia.
On the other hand, Noopept is considered an “active pharmaceutical ingredient” in theUnited States, so it is not to be sold directly to the consumer, but instead is only available forresearch and pharmaceutical development. Noopept is widely available without a prescription in Russia.
Noopept is also significantly less expensive than adrafinil, generally about half the price-ona gram-per-gram basis when the powder form is compared. We believe that this is because Noopept is more widely available, considering it is an over-the-counter drug in Russia, and because-on the whole-adrafinil is no longer widely used.
Finally, there are differing levels of research interest in these two compounds. Noopept is being actively studied, with many recent studies available in animals and humans. However because most of the interest in adrafinil has been redirected to its metabolite modafinil.there is little in the way of new research being done on adrafini-and most to date has been done in animals.

 

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