P2NP

P2NP CAS 705-60-2 product information:

synthesis of amphetamine sulphate using p2np

The most common route of synthesis is by the Leuckart method.This uses (P2P, BMK, phenylacetone) and reagents such as formic acid, ammonium formate or formamide to yield a racemic mixture of the R- and S-enantiomers. A much less common, but stereoselective, method is by reduction of the appropriate diastereoisomers of norephedrine or norpseudoephedrine. These precursors (1-phenyl-2-propanone, norephedrine and norpseudoephedrine) are listed in Table I of the United Nations 1988 Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances. The corresponding EU legislation is set out in Council Regulation (EEC) No 3677/90 (as later amended), which governs trade between the EU and third countries.

simple p2np synthesis

In the lab, phenyl-2-nitropropene is produced by the reaction of benzaldehyde and nitroethane in the presence of a basic catalyst like n-butylamine. The reaction is a nitroaldol reaction, and is a variant of a Knoevenagel condensation reaction, which is one of a broader class of reactions called Henry condensations, or simply Henry reactions. These are named after the German chemist Emil Knoevenagel, and the Belgian chemist Louis Henry, respectively.